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. 2021 Dec 2;12:751321. doi: 10.3389/fphar.2021.751321

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Copyright © 2021 Silva, Bicker, Fonseca, Ferreira, Vitorino, Alves, Falcão and Fortuna.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transepithelial electrical resistance (TEER) values of the RPMI 2650 cell line, measured in the EMEM medium or Hanks’ balanced salt solution (HBSS) with 10 mM HEPES (pH 7.4) with treatment conditions [free escitalopram and paroxetine (free drugs), NLC2, BorNLC, or NE], after the permeation assay. The paired student t-test was performed in comparison with the values obtained 24 h before the assay. NS, not significant, *p < 0.05 and ***p < 0.001. (A) Escitalopram apparent permeability coefficient (P_app) (B) and recovery values (C); paroxetine P_app (D) and recovery values (E) after a 3-h incubation with each treatment. One-way analysis of variance (ANOVA) with multiple comparison test was performed, *p < 0.05, **p < 0.01, and ***p < 0.001. All data are presented as mean ± standard deviation (n = 3 in triplicate).