Table 1.
Characteristics of Cases with Acute Retinal Necrosis
| Characteristic | Result |
|---|---|
| Number cases | 186 |
| Demographics | |
| Age, median, years (25th 75th percentile) | 50 (33, 63) |
| Gender (%) | |
| Men | 55 |
| Women | 45 |
| Race/ethnicity (%) | |
| White, non-Hispanic | 61 |
| Black, non-Hispanic | 10 |
| Hispanic | 2 |
| Asian, Pacific Islander | 15 |
| Other | 5 |
| Missing | 7 |
| Uveitis History | |
| Uveitis course (%) | |
| Acute, monophasic | 67 |
| Acute, recurrent | 4 |
| Chronic | 18 |
| Indeterminate | 11 |
| Laterality (%) | |
| Unilateral | 87 |
| Unilateral, alternating | 0 |
| Bilateral | 13 |
| Ophthalmic examination | |
| Keratic precipitates (%) | |
| None | 19 |
| Fine | 27 |
| Round | 18 |
| Stellate | 6 |
| Mutton Fat | 29 |
| Other | 1 |
| Anterior chamber cells (%) | |
| Grade 0 | 6 |
| 1/2+ | 9 |
| 1+ | 23 |
| 2+ | 27 |
| 3+ | 22 |
| 4+ | 12 |
| Anterior chamber flare (%) | |
| Grade 0 | 29 |
| 1+ | 32 |
| 2+ | 29 |
| 3+ | 9 |
| 4+ | 2 |
| Iris (%) | |
| Normal | 91 |
| Posterior synechiae | 6 |
| Iris nodules | 3 |
| Iris atrophy (sectoral, patchy, or diffuse) | 0 |
| Heterochromia | 0 |
| Intraocular pressure (IOP), involved eyes | |
| Median, mm Hg (25th, 75th percentile) | 15 (12, 19) |
| Proportion patients with IOP>24 mm Hg either eye (%) | 6 |
| Vitreous cells (%) | |
| Grade 0 | 7 |
| 1/2+ | 4 |
| 1+ | 31 |
| 2+ | 30 |
| 3+ | 21 |
| 4+ | 7 |
| Vitreous haze (%) | |
| Grade 0 | 20 |
| 1/2+ | 11 |
| 1+ | 19 |
| 2+ | 31 |
| 3+ | 16 |
| 4+ | 4 |
| Retinitis characteristics | |
| Number lesions (%) | |
| Unifocal (1) | 37 |
| Paucifocal (2 to 4) | 25 |
| Multifocal (≥5) | 36 |
| Lesion shape (%) | |
| Round or ovoid | 13 |
| Placoid | 24 |
| Wedge-shaped | 20 |
| Ameboid | 14 |
| Not determined | 28 |
| Lesion character (%) | |
| Circumferential | 30 |
| Confluent | 49 |
| Granular | 4 |
| Lesion location (%) | |
| Posterior pole and periphery involved | 18 |
| Mid-periphery and/or periphery only | 82 |
| Lesion size (%) | |
| <250 μm | 8 |
| 250–500 μm | 15 |
| >500 μm | 77 |
| Other features (%) | |
| Retinal vascular sheathing or leakage or occlusion | 54 |
| Hemorrhage | 38 |
| Systemic disease | |
| Immunocompromised patients (%) | 15 |
| Human immunodeficiency virus infection | 3 |
| Organ transplant | 0 |
| Chemotherapy or other immunosuppression | 12 |
| Laboratory data (%) | |
| Aqueous or vitreous specimen PCR* positive for HSV | 29 |
| Aqueous or vitreous specimen PCR* positive for VZV | 53 |
*
PCR = polymerase chain reaction. HSV = herpes simplex virus; 54 of 153 tested (35%) were positive. VZV = varicella zoster virus; 101 of 153 tested (66%) were positive. Two cases were positive for both viruses.