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. 2021 Dec 2;9:794769. doi: 10.3389/fbioe.2021.794769

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Copyright © 2021 Wang, Li, Ma, Sun, Hou, Huang, Zhang, Guo and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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In vitro biocompatibility and cell-proliferation tests. (A) Live/Dead staining of a) EGF@PLC3, b) BM@PLC3, c) PLC3, d) EGF, e) BM, and f) control; scale bar: 100 μm. (B) CCK-8 for blank hydrogels. (C) CCK-8 for hydrogels loaded with drugs. (D) Hemolysis test on a) PLC3, b) PLC3-1, c) PLC3-2, d) PLC3-3, e) BM@PLC3, f) EGF@PLC3, g) Ultra-pure water, and h) saline. (E) The quantitative result of hemolysis test. (F) Cell scratch test on a) EGF@PLC3, b) EGF, c) PLC3, and d) control groups. (G) Measuring analysis on cell scratch test. With the data shown as means ± SD (n = 3).