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APOE genotyping is determined by promoter polymorphisms of two single nucleotides (rs429358 and rs rs7412).
| APOE genotypes | S1:rs429358 | S2:rs7412 |
| E2/E2 | T/T | T/T |
| E3/E3 | T/T | C/C |
| E4/E4 | C/C | C/C |
| E2/E3 | T/T | T/C |
| E2/E4 | T/C | T/C |
| E3/E4 | T/C | C/C |
T or C represents the first DNA base of the nucleotides.
