TABLE 1.
Sample demographics bipolar disorder family cohorts
| Total | IQ scores | Educational attainment | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Controls | Patients | Relatives | Controls | Patients | Relatives | Controls | Patients | Relatives | |||||||||||||
| Sample | N | M/F | Age | N | M/F | Age | N | M/F | Age | N | IQ | N | IQ | N | IQ | N | EA | N | EA | N | EA |
| BPO‐FLB | 7 | 3/4 | 12.9 (1.3) | 9 | 5/4 | 13.3 (2.6) | 22 | 10/12 | 10.0 (3.5) | 7 | 91.0 (10.2) | 5 | 91.2 (16.1) | 7 | 95.4 (17.3) | — | — | — | |||
| Cardiff | 79 | 28/51 | 39.8 (8.7) | 120 | 42/78 | 41.9 (8.1) | 33 | 13/20 | 45.9 (6.9) | — | — | — | — | — | — | ||||||
| CliNG‐BD a | 19 | 6/13 | 30.9 (9.6) | — | 19 | 6/13 | 31.9 (5.0) | — | — | — | 12 | 14.9 (3.3) | — | 10 | 15.2 (3.2) | ||||||
| DEU | 27 | 11/16 | 32.9 (8.8) | 27 | 10/17 | 36.3 (9.5) | 23 | 11/12 | 31.3 (8.9) | — | — | — | 21 | 13.1 (4.1) | 24 | 12.9 (2.9) | 14 | 11.6 (3.1) | |||
| EGEU | 33 | 13/20 | 33.6 (7.8) | 27 | 16/11 | 36.7 (7.8) | 27 | 10/17 | 34.5 (9.5) | — | — | — | 28 | 11.6 (3.8) | 26 | 10.8 (4.2) | 23 | 10.8 (4.4) | |||
| ENBD‐UT | 36 | 13/23 | 34.8 (11.7) | 72 | 23/49 | 36.9 (12.4) | 52 | 10/42 | 44.3 (13.6) | 27 | 101.0 (14.5) | 40 | 97.0 (12.0) | 19 | 99.2 (14.4) | 26 | 15.2 (3.0) | 55 | 14.7 (2.3) | 46 | 15.1 (2.3) |
| FIDMAG‐Clinic | 61 | 12/49 | 41.1 (10.1) | 18 | 3/15 | 42.6 (8.8) | 18 | 5/13 | 45.1 (10.0) | 61 | 112.9 (13.6) | 14 | 101.9 (13.1) | 16 | 105.8 (16.7) | — | — | — | |||
| Geneva | 19 | 10/9 | 20.1 (2.7) | — | 18 | 9/9 | 19.4 (3.1) | — | — | — | — | — | — | ||||||||
| IDIBAPS a | 53 | 21/32 | 12.3 (3.6) | — | 61 | 31/30 | 12.4 (3.4) | 53 | 106.1 (12.4) | — | 61 | 107.0 (13.0) | — | — | — | ||||||
| IoP‐BD | 39 | 9/30 | 35.4 (11.2) | 34 | 15/19 | 40.6 (13.1) | 17 | 4/13 | 43.1 (14.6) | — | — | — | 31 | 15.2 (2.6) | 26 | 15.4 (3.2) | 14 | 16.4 (2.6) | |||
| MFS‐BD a | 54 | 25/29 | 40.2 (15.3) | 38 | 15/23 | 41.0 (11.7) | 41 | 17/24 | 49.3 (9.6) | 39 | 110.8 (16.1) | 31 | 97.4 (11.7) | 34 | 100.0 (10.3) | 35 | 14.1 (3.9) | 35 | 13.9 (3.3) | 31 | 14.6 (4.0) |
| MooDS‐BD a | 63 | 25/38 | 30.3 (9.5) | — | 63 | 25/38 | 30.4 (9.4) | 62 | 99.4 (5.5) | — | 62 | 101.5 (5.8) | 33 | 15.4 (2.4) | — | 34 | 17.2 (2.8) | ||||
| MSSM | 52 | 25/27 | 35.2 (13.0) | 41 | 21/20 | 44.3 (11.9) | 50 | 26/24 | 33.8 (8.3) | — | — | — | — | — | — | ||||||
| Olin | 68 | 25/43 | 32.2 (11.7) | 108 | 34/74 | 34.5 (12.3) | 78 | 30/48 | 32.0 (13.0) | 54 | 107.0 (15.0) | 95 | 102.9 (15.6) | 68 | 105.6 (15.1) | 40 | 15.2 (2.4) | 74 | 14.6 (2.2) | 40 | 14.6 (2.2) |
| ORBIS‐I | 32 | 12/20 | 20.7 (3.3) | 6 | 0/6 | 22.9 (4.0) | 39 | 13/26 | 19.8 (3.2) | — | — | — | — | — | — | ||||||
| ORBIS‐II | 18 | 7/11 | 23.0 (3.5) | 8 | 3/5 | 24.0 (5.0) | 26 | 10/16 | 19.9 (4.0) | — | — | — | — | — | — | ||||||
| PENS‐BD a | 16 | 6/10 | 45.9 (10.1) | 20 | 14/6 | 46.9 (10.4) | 9 | 5/4 | 40.4 (6.3) | 16 | 115.7 (13.8) | 20 | 103.7 (15.8) | 9 | 101.3 (18.0) | 16 | 16.0 (1.3) | 19 | 14.8 (2.7) | 9 | 15.0 (1.6) |
| PHCP‐BD a | 38 | 21/17 | 38.4 (13.7) | 29 | 7/22 | 32.2 (11.6) | 7 | 2/5 | 51.0 (6.1) | 38 | 106.3 (11.8) | 29 | 101.8 (8.8) | 7 | 100.6 (9.1) | 29 | 16.0 (2.5) | 18 | 14.8 (1.8) | 7 | 15.4 (1.5) |
| STAR‐BD a | 83 | 39/44 | 49.0 (10.4) | 25 | 7/18 | 45.8 (10.1) | 21 | 6/15 | 47.9 (11.3) | — | — | — | 81 | 11.9 (2.9) | 25 | 12.9 (3.6) | 21 | 11.5 (2.5) | |||
| SydneyBipolarGroup | 117 | 54/63 | 22.2 (3.9) | 59 | 17/42 | 25.1 (3.6) | 150 | 65/85 | 19.9 (5.4) | 116 | 117.6 (10.3) | 57 | 116.2 (12.3) | 147 | 114.5 (10.6) | 24 | 17.1 (3.2) | 32 | 16.4 (2.3) | 30 | 15.9 (2.2) |
| UMCU‐BD twins a | 110 | 40/70 | 39.3 (9.2) | 52 | 13/39 | 39.6 (9.7) | 27 | 9/18 | 41.7 (9.3) | 48 | 98.0 (13.5) | 22 | 92.4 (13.2) | 14 | 95.4 (14.1) | 108 | 13.4 (2.7) | 47 | 12.7 (2.6) | 26 | 12.1 (2.6) |
| UMCU‐DBSOS a | 40 | 21/19 | 12.7 (2.1) | — | 66 | 37/29 | 14.7 (2.7) | 40 | 117.1 (13.0) | — | 63 | 106.7 (18.3) | — | — | — | ||||||
a
Overlapping controls with schizophrenia sample from the same site, that is, with CliNG‐SZ (n = 10), IDIBAPS (n = 53), MFS‐SZ (n = 54), MooDS‐SZ (n = 36), PENS‐SZ (n = 16), PHCP‐SZ (n = 38), STAR‐SZ (n = 73), UMCU‐UTWINS (n = 19), UMCU‐DBSOS (n = 40).