FIGURE 1.

Reproducibility in the absence of selective reporting, estimated based on outputs of the ENIGMA cortical asymmetry project. (a) Sample size distribution of the 99 datasets. (b) Effect size distribution of the 70 hemispheric effects of interest. (c) Reproducibility distribution of the 70 hemispheric effects. The reproducibility was assessed by comparing each dataset in turn to the meta‐analytic effect from the 98 others, to avoid overlap (see Methods). (d) Scatter plot of the correlation between the reproducibility and the effect size. (e) Relations of reproducibility, effect size and dataset sample size. Each line plots the mean and 95% confidence interval for reproducibility. We used the meta‐analytic effect size over all 99 datasets for visualization purposes. The figure key shows the types of cortical measure (orange indicates surface area; green indicates cortical thickness), as well as groupings by true effect sizes