TABLE 4.

Effect sizes (Cohen's d) for RVI for early (up to 5 years since diagnosis), intermediate (6–20 years), and chronic (21+ years) patients versus controls

Patient groups	Cortical	Subcortical	White matter	Multimodality
Early	1.19 (p = 3 × 10−9)	0.46 (p = 9 × 10−9)	0.43 (p = .03)	1.27 (p = 2 × 10−9)
Intermediate	1.21 (p = 9 × 10−10)	0.83 (p = 5 × 10−4)	1.09 (p = 4 × 10−6)	1.79 (p = 2 × 10−12)
Chronic	1.16 (p = 3 × 10−8)	0.74 (p = 7 × 10−7)	1.55 (p = 9 × 10−13)	1.89 (p = 5 × 10−17)

Abbreviation: RVI, regional vulnerability index.