Fig. 4.

Mediation analyses of Aβ and longitudinal cognition with biomarkers as mediators in MCI. The bold p values indicate the mediation pathways are meaningful among the MCI participants. The proportions shown in the figure indicate the proportion of mediating factors in the total effect of amyloid pathology on cognition. MCI, mild cognitive impairment; Aβ, amyloid-β; p-tau, phosphorylated tau; t-tau, total tau; NFL, neurofilament light; sTREM2, soluble triggering receptor on myeloid cells 2; MEM, memory function; EF, executive function; LAN, language; VS, visuospatial functioning