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. 2021 Dec 15;22:78. doi: 10.1186/s12868-021-00683-8

Fig. 5.

Fig. 5

Metformin alleviates CLP-induced synaptic dysfunction. A, B CA3-CA1 fEPSP mean slope recorded from the CA1 dendritic region in hippocampal slices, n  = 3. Hippocampal tissues were homogenized, and synaptic protein levels were detected by immunoblotting (C). Postsynaptic proteins NR2B (D), PSD95 (E) and pre-synaptic proteins SYN (F), SYT (G) were evaluated. n  =  3. p value significance is calculated from a one-way ANOVA or two-way ANOVA tests, all data represent mean  ±  SEM. *p  < 0.05, **p  < 0.01 vs CLP group