Table 2. List of representative VSRs in mammalian cells.
| Virus | VSR | Mechanism | Reference |
|---|---|---|---|
| IAV | NS1 | dsRNA binding | Li and colleagues [29] |
| NoV | B2 | dsRNA binding | Sullivan and colleagues [28] |
| HIV-1 | Tat | dsRNA binding | Bennasser and colleagues [32] |
| HBV | HBx | dsRNA binding | Chinnappan and colleagues [33] |
| HCV | Capsid | Interaction with Dicer | Wang and colleagues [34] |
| NS2 | dsRNA binding | Zhou and colleagues [35] | |
| SFV | Capsid | dsRNA binding | Qian and colleagues [36] |
| Ebola virus | VP30, VP35, VP40 | Interaction with Dicer, TRBP, or PACT/dsRNA binding | Haasnoot and colleagues [30] Fabozzi and colleagues [37] |
| Marburg virus | VP35 | dsRNA binding | Li and colleagues [31] |
| Dengue virus | NS4B | dsRNA nonbinding | Kakumani and colleagues [38] |
| NS3 | Interaction with HSC70 | Kakumari and colleagues [39] | |
| NS2A | dsRNA binding | Qiu and colleagues [40] | |
| HEV71 | 3A | dsRNA binding | Qiu and colleagues [41] |
| CoV | N | dsRNA binding | Cui and colleagues [42] |
| SARS-CoV | 7A | - | Karjee and colleagues [43] |
| SARS-CoV-2 | N | - | Mu and colleagues [44] |
| Adenovirus | VA1 RNA, VA2 RNA | Binding to Dicer | Lu and Cullen [45] Andersson and colleagues [46] |
Note that we list only the first report, to our knowledge, that each of these proteins has VSR activity.
CoV, coronavirus; dsRNA, double-stranded RNA; HBV, hepatitis B virus; HCV, hepatitis C virus; HEV71, human enterovirus 71; HIV-1, human immunodeficiency virus 1; IAV, influenza A virus; NoV, Nodamura virus; NS1, nonstructural protein 1; SARS-CoV, severe acute respiratory syndrome–associated coronavirus; SARS-CoV-2, severe acute respiratory syndrome–associated coronavirus-2; SFV, Semliki forest virus; VP30, virion protein 30; VSR, viral suppressor of RNAi.