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. 2021 Dec 16;17(12):e1009938. doi: 10.1371/journal.pgen.1009938

Fig 10. A hypothetical functional model of neuronal subsets localising ChT at glomerulus of MB calyx to regulate olfactory habituation.

Fig 10

Left panel, PNs carries olfactory information to the calyx of MB and activate inhibition of MB neurons via activation of GABAergic inhibitory neurons. Both excitatory PNs and inhibitory GABAergic neurons require ChT for the forward inhibition and permit control over the MB neurons to respond to input stimuli. There are two possibilities through which ChT in MBs may further manifest control over incoming stimuli as depicted in the figure (black dashed lines): a feedback inhibition of incoming stimuli via GABAergic neurons which inturn may inhibit output from excitatory PNs or a feedforward inhibition of incoming stimuli. Right panel, if ChT in PNs, GABAergic or MB intrinsic neuron is depleted (shown as a red no-sign icon), the habituation is defective and the control over the incoming stimuli is lost, leading to enhanced chemotaxis towards odour, as presented in our results.