Table 2. Constrained analysis of principal coordinates of GI/UG bacterial communities and the levels of estrogen and its metabolites.
| Gut Microbial | Vagina Microbial | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Source of variation | DF | Sum of Sqs | Residual | F | P value | Sum of Sqs | Residual | F | P value |
| Estradiol | 4 | 1.91 | 11.88 | 1.12 | 0.021 | 1.79 | 12.52 | 0.97 | 0.83 |
| 16keto-17β-estradiol | 4 | 1.88 | 17.06 | 1.13 | 0.024 | 1.78 | 18.79 | 0.97 | 0.74 |
| Estriol | 4 | 1.87 | 17.03 | 1.1 | 0.035 | 1.72 | 18.43 | 0.93 | 0.97 |
| 2-hydroxyestradiol | 4 | 1.89 | 19.14 | 1.1 | 0.036 | 1.79 | 20.97 | 0.98 | 0.71 |
| 2-hydroxyestrone | 4 | 1.95 | 19.66 | 1.14 | 0.01 | 1.74 | 21.20 | 0.95 | 0.92 |
Statistically significant explanatory variables are in bold and italic.