Table 3.
Univariate regression results.
| Univariate Analysis | Mobility | Self-care | Usual activities | Pain/discomfort | Anxiety/depression | EQ-VAS | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Effect | SE | p-value | Effect | SE | p-value | Effect | SE | p-value | Effect | SE | p-value | Effect | SE | p-value | Effect | SE | p-value | |
| Gender | ||||||||||||||||||
| Female (ref.) | ||||||||||||||||||
| Male | −0.076 | 0.075 | 1.8342 | 0.011 | 0.073 | 5.3184 | 0.094 | 0.081 | 1.4568 | −0.042 | 0.053 | 2.5836 | −0.070 | 0.055 | 1.2462 | −1.339 | 1.465 | 2.1642 |
| Age | 0.021 | 0.003 | <0.001 | 0.013 | 0.003 | <0.001 | 0.015 | 0.003 | <0.001 | −0.003 | 0.002 | 1.3872 | −0.001 | 0.002 | 3.7896 | −0.202 | 0.057 | 0.0024 |
| Progression status | ||||||||||||||||||
| Non-progressed | ||||||||||||||||||
| Progressed | 0.656 | 0.077 | <0.001 | 0.692 | 0.074 | <0.001 | 0.696 | 0.083 | <0.001 | 0.289 | 0.057 | <0.001 | 0.311 | 0.058 | <0.001 | −16.973 | 1.483 | <0.001 |
| Current treatment | ||||||||||||||||||
| TTFields only | ||||||||||||||||||
| TTFields + others | 0.168 | 0.073 | 0.1272 | 0.189 | 0.071 | 0.048 | 0.242 | 0.078 | 0.0114 | 0.152 | 0.052 | 0.0198 | 0.104 | 0.053 | 0.2886 | −5.106 | 1.433 | 0.0024 |
| Time since diagnosis | ||||||||||||||||||
| 0–15 months | ||||||||||||||||||
| >15 months | −0.090 | 0.072 | 1.2486 | −0.182 | 0.071 | 0.06 | −0.259 | 0.077 | 0.0042 | −0.017 | 0.051 | 4.4196 | −0.087 | 0.053 | 0.5838 | 3.800 | 1.421 | 0.045 |
| Time since diagnosis | −0.001 | 0.001 | 3.6018 | −0.002 | 0.001 | 1.2486 | −0.003 | 0.002 | 0.3354 | 0.000 | 0.001 | 4.2576 | −0.001 | 0.001 | 3.6606 | 0.066 | 0.028 | 0.1134 |
| Log(Time since diagnosis) | −0.044 | 0.048 | 2.1426 | −0.099 | 0.047 | 0.2148 | −0.139 | 0.051 | 0.0396 | 0.008 | 0.034 | 4.917 | −0.029 | 0.035 | 2.4438 | 2.286 | 0.950 | 0.0966 |
| Time on TTFields | −0.008 | 0.003 | 0.0276 | −0.012 | 0.003 | <0.001 | −0.013 | 0.003 | <0.001 | −0.004 | 0.002 | 0.3342 | −0.003 | 0.002 | 0.7782 | 0.219 | 0.055 | <0.001 |
| Log(Time on TTFields) | −0.121 | 0.037 | 0.0066 | −0.165 | 0.036 | <0.001 | −0.172 | 0.039 | <0.001 | −0.051 | 0.026 | 0.3132 | −0.047 | 0.027 | 0.5034 | 2.631 | 0.731 | 0.0018 |
Entries with light shading denote statistically significant deterioration, while those with dark shading indicate statistically significant improvement. Within the EQ-5D subscales (mobility, self-care, usual activities, pain/discomfort, and anxiety/depression), lower scores indicate less impairment and higher scores more impairment in health-related quality of life (HRQoL). For EQ-VAS, higher values indicate improved self-rated health and lower values indicate worse self-rated health. Quoted p-values = raw p-values × 6 to adjust for multiple comparisons.
EQ-VAS, EuroQol’s visual analogue scale; TTFields, tumor treating fields.