Table 4.

Multivariate regression results with time since diagnosis.

Multivariate regression	Mobility			Self-care			Usual activities			Pain/discomfort			Anxiety/depression			VAS
	Effect	SE	p-value	Effect	SE	p-value	Effect	SE	p-value	Effect	SE	p-value	Effect	SE	p-value	Effect	SE	p-value
Gender
Female (ref.)
Male	−0.024	0.076	1.5126	0.035	0.075	1.273	0.152	0.082	0.1298	−0.046	0.057	0.8408	−0.060	0.058	0.5974	−1.288	1.467	0.7598
Age	0.021	0.003	<0.001	0.013	0.003	<0.001	0.016	0.003	<0.001	−0.002	0.002	0.897	−0.001	0.002	1.463	−0.182	0.058	0.0032
Progression status
Non-progressed
Progressed	0.688	0.081	<0.001	0.714	0.080	<0.001	0.727	0.088	<0.001	0.291	0.061	<0.001	0.324	0.062	<0.001	−16.922	1.571	<0.001
Current treatment
TTFields only
TTFields + others	−0.005	0.081	1.8966	−0.015	0.080	1.7024	0.013	0.088	1.7706	0.135	0.061	0.0516	0.000	0.062	1.9968	−0.349	1.568	1.6478
Time since diagnosis
0–15 months
>15 months	−0.056	0.080	0.9598	−0.191	0.078	0.0296	−0.250	0.086	0.0076	0.043	0.059	0.9382	−0.083	0.061	0.3518	3.948	1.538	0.0204

Entries with light shading denote statistically significant deterioration, while those with dark shading indicate statistically significant improvement. Within the EQ-5D subscales (mobility, self-care, usual activities, pain/discomfort, and anxiety/depression), lower scores indicate less impairment and higher scores more impairment in health-related quality of life (HRQoL). For EQ-VAS, higher values indicate improved self-rated health and lower values indicate worse self-rated health. Quoted p-values = raw p-vales × 2 to adjust for multiple comparisons.

VAS, EuroQol’s visual analogue scale; TTFields, tumor treating fields.