Table 5.

Multivariate regression results with time on TTFields.

Multivariate regression	Mobility			Self-care			Usual activities			Pain/discomfort			Anxiety/depression			VAS
	Effect	SE	p-value	Effect	SE	p-value	Effect	SE	p-value	Effect	SE	p-value	Effect	SE	p-value	Effect	SE	p-value
Gender
Female (ref.)
Male	−0.020	0.078	1.5944	0.064	0.076	0.8024	0.133	0.084	0.2266	−0.046	0.059	0.8608	−0.053	0.060	0.752	−0.929	1.506	1.0744
Age	0.021	0.003	<0.001	0.012	0.003	<0.001	0.017	0.003	<0.001	−0.0005	0.002	1.688	0.000	0.002	1.787	−0.186	0.059	0.0032
Progression status
Non-progressed
Progressed	0.697	0.083	<0.001	0.707	0.081	<0.001	0.724	0.089	<0.001	0.337	0.062	<0.001	0.342	0.063	<0.001	−17.122	1.592	<0.001
Current treatment
TTFields only
TTFields + others	−0.032	0.083	1.406	−0.047	0.081	1.1276	0.013	0.089	1.7774	0.098	0.063	0.2326	0.005	0.064	1.8684	0.269	1.599	1.7328
Time on TTFields	−0.006	0.003	0.1236	−0.011	0.003	0.0006	−0.011	0.003	0.0022	−0.002	0.002	0.7402	−0.002	0.002	0.5962	0.189	0.058	0.0022
Gender
Female (ref.)
Male	−0.025	0.078	1.493	0.058	0.077	0.903	0.126	0.085	0.2702	−0.052	0.059	0.7516	−0.054	0.060	0.7412	−0.812	1.511	1.1818
Age	0.022	0.003	<0.001	0.013	0.003	<0.001	0.017	0.003	<0.001	−0.0002	0.002	1.835	0.0000	0.002	1.975	−0.198	0.059	0.0014
Progression status
Non-progressed
Progressed	0.687	0.083	<0.001	0.696	0.081	<0.001	0.711	0.089	<0.001	0.329	0.063	<0.001	0.338	0.064	<0.001	−16.897	1.598	<0.001
Current treatment
TTFields only
TTFields + others	−0.053	0.085	1.0708	−0.059	0.084	0.955	−0.001	0.092	1.9904	0.102	0.064	0.2252	−0.010	0.066	1.7602	0.200	1.640	1.8056
Log(Time on TTFields)	−0.095	0.042	0.0476	−0.142	0.041	0.0012	−0.151	0.045	0.0018	−0.024	0.032	0.8858	−0.048	0.032	0.277	2.233	0.812	0.012

Entries with light shading denote statistically significant deterioration, while those with dark shading indicate statistically significant improvement. Within the EQ-5D subscales (mobility, self-care, usual activities, pain/discomfort, and anxiety/depression), lower scores indicate less impairment and higher scores more impairment in health-related quality of life (HRQoL). For EQ-VAS, higher values indicate improved self-rated health and lower values indicate worse self-rated health. Quoted p-values = raw p-values × 2 to adjust for multiple comparisons.

VAS, visual analogue scale; TTFields, tumor treating fields.