Table 7.

Multivariate regression results for the non-progressed and progressed subgroups with time since diagnosis.

Multivariate regression	Mobility			Self-care			Usual activities			Pain/discomfort			Anxiety/depression			VAS
	Effect	SE	p-value	Effect	SE	p-value	Effect	SE	p-value	Effect	SE	p-value	Effect	SE	p-value	Effect	SE	p-value
Non-progressed
Gender
Female (ref.)
Male	−0.090	0.079	0.5118	−0.040	0.074	1.171	0.085	0.094	0.7234	−0.030	0.063	1.2604	−0.043	0.068	1.0436	−0.295	1.612	1.7096
Age	0.021	0.003	<0.001	0.012	0.003	<0.001	0.014	0.004	<0.001	0.000	0.002	1.9988	0.000	0.003	1.9844	−0.150	0.061	0.0278
Current treatment
TTFields only
TTFields + others	0.127	0.079	0.218	0.167	0.074	0.0466	0.199	0.093	0.0656	0.139	0.062	0.0512	0.039	0.067	1.1294	−3.796	1.600	0.0354
Time since diagnosis	0.005	0.002	0.0082	0.004	0.002	0.0338	0.001	0.002	1.0682	0.003	0.001	0.1172	0.001	0.002	1.411	−0.002	0.036	1.8988
Gender
Female (ref.)
Male	−0.091	0.079	0.5064	−0.040	0.074	1.1836	0.086	0.094	0.7212	−0.030	0.063	1.2592	−0.043	0.068	1.053	−0.305	1.612	1.6994
Age	0.021	0.003	<0.001	0.011	0.003	<0.001	0.014	0.004	<0.001	0.000	0.002	1.8524	0.000	0.003	1.937	−0.150	0.061	0.0282
Current treatment
TTFields only
TTFields + others	0.177	0.085	0.0762	0.183	0.080	0.0428	0.197	0.100	0.1	0.164	0.067	0.0296	0.027	0.073	1.4222	−3.593	1.726	0.0748
Log(Time since diagnosis)	0.165	0.059	0.0106	0.092	0.055	0.191	0.018	0.070	1.5838	0.084	0.047	0.144	−0.009	0.050	1.7116	0.288	1.198	1.6204
Progressed
Gender
Female (ref.)
Male	0.064	0.173	1.426	0.121	0.179	0.9986	0.236	0.168	0.3204	−0.098	0.121	0.8362	−0.120	0.114	0.5812	−1.431	3.102	1.2894
Age	0.023	0.007	0.0036	0.017	0.008	0.056	0.021	0.007	0.0072	−0.006	0.005	0.4914	−0.003	0.005	1.0734	−0.272	0.132	0.0778
Current treatment
TTFields only
TTFields + others	−0.165	0.178	0.709	−0.167	0.186	0.7382	−0.136	0.175	0.8748	0.123	0.127	0.6668	0.009	0.118	1.878	4.662	3.232	0.2984
Time since diagnosis	−0.005	0.003	0.113	−0.007	0.003	0.0158	−0.006	0.003	0.047	−0.002	0.002	0.6616	−0.002	0.002	0.445	0.164	0.050	0.002
Gender
Female (ref.)
Male	0.085	0.171	1.2402	0.152	0.177	0.7806	0.258	0.166	0.2408	−0.083	0.121	0.9828	−0.106	0.113	0.6928	−2.365	3.105	0.8928
Age	0.023	0.007	0.0038	0.017	0.008	0.0602	0.021	0.007	0.0078	−0.006	0.005	0.5102	−0.003	0.005	1.0894	−0.271	0.133	0.0846
Current treatment
TTFields only
TTFields + others	−0.218	0.182	0.4656	−0.239	0.190	0.4174	−0.200	0.179	0.5264	0.135	0.130	0.6012	0.006	0.122	1.9194	5.110	3.340	0.252
Log(Time since diagnosis)	−0.222	0.105	0.0694	−0.320	0.109	0.007	−0.271	0.103	0.0162	−0.013	0.075	1.7214	−0.053	0.070	0.9108	4.708	1.967	0.0334

Entries with light shading denote statistically significant deterioration, while those with dark shading indicate statistically significant improvement. Within the EQ-5D subscales (mobility, self-care, usual activities, pain/discomfort, and anxiety/depression), lower scores indicate less impairment and higher scores more impairment in health-related quality of life (HRQoL). For EQ-VAS, higher values indicate improved self-rated health and lower values indicate worse self-rated health. Quoted p-values = raw p-vales × 2 to adjust for multiple comparisons.

VAS, visual analogue scale; TTFields, tumor treating fields.