Table 8.

Multivariate regression results for the non-progressed and progressed subgroups with time on TTFields.

Multivariate regression	Mobility			Self-care			Usual activities			Pain/discomfort			Anxiety/depression			VAS
	Effect	SE	p-value	Effect	SE	p-value	Effect	SE	p-value	Effect	SE	p-value	Effect	SE	p-value	Effect	SE	p-value
Non-progressed
Gender
Female (ref.)
Male	−0.063	0.083	0.9002	0.021	0.076	1.5748	0.089	0.096	0.7056	−0.019	0.065	1.5478	−0.028	0.070	1.3758	−0.284	1.649	1.7262
Age	0.021	0.003	<0.001	0.010	0.003	0.0006	0.014	0.004	<0.001	0.001	0.002	1.411	0.001	0.003	1.6354	−0.142	0.062	0.043
Current treatment
TTFields only
TTFields + others	0.062	0.088	0.962	0.048	0.081	1.1042	0.106	0.101	0.5918	0.084	0.068	0.4344	−0.014	0.074	1.695	−1.913	1.735	0.5406
Time on TTFields	−0.001	0.003	1.5832	−0.006	0.003	0.137	−0.008	0.004	0.0846	−0.002	0.003	0.8242	−0.004	0.003	0.3104	0.151	0.065	0.0394
Gender
Female (ref.)
Male	−0.068	0.083	0.8232	0.016	0.077	1.6668	0.082	0.096	0.7924	−0.025	0.065	1.397	−0.030	0.070	1.3306	−0.238	1.654	1.771
Age	0.021	0.003	<0.001	0.011	0.003	0.0004	0.015	0.004	<0.001	0.0011	0.002	1.3072	0.0009	0.003	1.4432	−0.154	0.062	0.0258
Current treatment
TTFields only
TTFields + others	0.064	0.091	0.9696	0.046	0.084	1.1766	0.096	0.105	0.719	0.098	0.071	0.3352	−0.005	0.077	1.9014	−1.838	1.795	0.6114
Log(Time on TTFields)	−0.018	0.046	1.4058	−0.074	0.043	0.163	−0.117	0.053	0.0558	−0.018	0.036	1.2316	−0.040	0.039	0.5988	1.998	0.912	0.057
Progressed
Gender
Female (ref.)
Male	0.047	0.174	1.5754	0.130	0.181	0.947	0.203	0.169	0.456	−0.103	0.125	0.8248	−0.104	0.117	0.7458	−1.556	3.186	1.2504
Age	0.024	0.008	0.0022	0.020	0.008	0.025	0.025	0.007	0.0014	−0.005	0.005	0.79	−0.004	0.005	0.9358	−0.338	0.137	0.0274
Current treatment
TTFields only
TTFields + others	−0.215	0.189	0.5096	−0.241	0.197	0.4418	−0.204	0.184	0.5362	0.136	0.137	0.6422	0.038	0.127	1.5252	5.722	3.494	0.203
Time on TTFields	−0.015	0.006	0.0386	−0.021	0.007	0.003	−0.017	0.006	0.0142	−0.002	0.005	1.4742	0.001	0.004	1.67	0.271	0.118	0.044
Gender
Female (ref.)
Male	0.039	0.174	1.6426	0.118	0.181	1.0298	0.195	0.169	0.496	−0.109	0.125	0.7696	−0.107	0.117	0.7178	−1.351	3.200	1.346
Age	0.025	0.007	0.0014	0.020	0.008	0.0206	0.025	0.007	0.0014	−0.0041	0.005	0.9004	−0.0027	0.005	1.1764	−0.342	0.138	0.0262
Current treatment
TTFields only
TTFields + others	−0.263	0.189	0.3284	−0.259	0.199	0.386	−0.214	0.186	0.4986	0.119	0.138	0.7782	−0.018	0.128	1.7724	5.304	3.530	0.266
Log(Time on TTFields)	−0.240	0.088	0.0126	−0.274	0.092	0.0058	−0.213	0.086	0.026	−0.035	0.063	1.1624	−0.061	0.060	0.6092	2.540	1.633	0.2396

Entries with light shading denote statistically significant deterioration, while those with dark shading indicate statistically significant improvement. Within the EQ-5D subscales (mobility, self-care, usual activities, pain/discomfort, and anxiety/depression), lower scores indicate less impairment and higher scores more impairment in health-related quality of life (HRQoL). For EQ-VAS, higher values indicate improved self-rated health and lower values indicate worse self-rated health. Quoted p-values = raw p-vales × 2 to adjust for multiple comparisons.

VAS, visual analogue scale; TTFields, tumor treating fields.