Table 1. Secreted Cytokine Amounts (in picograms) Detected in Sera of Mice Vaccinated with our MUC4 Glycopeptide B13G Gold Nanoparticle or a Conjugate of That Same Glycopeptide with CRM197.
| vaccination
epitope |
||||
|---|---|---|---|---|
| B13G-TF-Ser(5)-MUC4-AuNP/SAS | TF-Ser(5)-MUC4-CRM | B13G-AuNP | PBS | |
| cytokine detected | amount (pg) | |||
| IL-1β | 271 | 3806 | 5 | 0 |
| IL-5 | 192 | 3121 | 13 | 7 |
| IL-6 | 308 | 4245 | 14 | 0 |
| IL-17 | 14 | 162 | 3 | 2 |
| IL-21 | 38 | 0 | 0 | 0 |
| IL-23 | 2912 | 19304 | 448 | 89 |
| INF-γ | 485 | 5367 | 52 | 12 |
| MIP1α | 11 | 181 | 1 | 11 |
| IL-10 | 0 | 0 | 0 | 0 |
| TGF-βa | 0 | 71000 | 0 | 0 |