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. 2021 Dec 16;16(12):e0261127. doi: 10.1371/journal.pone.0261127

Fig 7. Met suppresses cartilage degeneration by inhibiting osteoclastogenesis in the early stage of DMM-induced OA.

Fig 7

The DMM-induced OA mice were treated with or without Met for 4 and 8 weeks, and histological analysis of osteoclasts in subchondral and cartilage were stained with (A) TRAP, (B) HE and (C) Safranin O-Fast Green respectively. Scale bar, 100 μm. Quantitative analysis of (D) Oc.S/BS, (E) CC/TAC, and (F) OARSI scores. n = 5 per group/time point. **P < 0.01 and ***P < 0.001, compared with the sham-operated group.