Fig 8. Met inhibits RANKL, NF-κB expression and promoted p-AMPK expression in the early stage of DMM-induced OA.

The DMM-induced OA mice were treated with or without DHA for 4 weeks, and expression of (A) RANKL, (C) p-AMPK, and (E) NF-κB was shown by immunohistochemistry staining. Scale bar, 100 μm. Quantitative analysis of (B) RANKL, (D) p-AMPK, and (F) NF-κB. n = 5 per group/time point. ***P < 0.001, compared with the sham-operated group.