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. 2021 Dec 2;15:773375. doi: 10.3389/fncel.2021.773375

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Copyright © 2021 Wang, Gu, Gan, Tian, Zhang, Zhao and Lei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transplantation of NGF-modified NSCs improved functional recovery of hindlimbs and alleviated histopathological damage after SCI. (A–C) After NGF-NSCs transplantation, NGF-NSCs rats exhibited steady and significantly better improvement of hindlimbs’ motor function along time in BBB score (A), inclined plane test (B), and grid walking test (C). (D) NGF-NSCs transplantation ameliorated the histopathological damage in the lesion epicenter 4 weeks after treatments. The area of injured tissue was circled by red dash lines in the representative transverse sections. The quantified analysis revealed that NGF-NSCs rats had a smaller area of damaged tissue and a larger size of spared tissue in the lesion site. ^∗p < 0.05, ^∗∗p < 0.01, and ^∗∗∗p < 0.001.