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. 2021 Dec 2;15:773375. doi: 10.3389/fncel.2021.773375

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Copyright © 2021 Wang, Gu, Gan, Tian, Zhang, Zhao and Lei.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NGF-modified NSCs transplantation protected motor neurons and enhanced endogenous neurogenesis in the peri-lesion segments. (A,B) Four weeks after NGF-NSCs transplantation, compared to the sham group, the percentage of β-tubulin3 positive area in the anterior horn was significantly higher, and the neurons maintained physiological morphology. (C) Around the central canal in the peri-lesion segments (3 mm caudal to the lesion epicenter), there were no positive signals of ZsGreen and the immunoactivity of nestin was higher in the rat receiving NGF-NSCs along the time. (D) In the control rats, the expression of nestin was weak around central canal and there were no ZsGreen + cells. (E) The semi-quantification of the percentage of nestin + area demonstrated that high expression of nestin in the peri-lesion segments of NGF-NSCs rats. Scale bar = 20 μm. *p < 0.05 and **p < 0.01.