Figure S3. Reduced β-arrestin1 decreases tau levels.

(A) HeLa-V5-tau cells were transfected with control siRNA or β-arrestin1 siRNA, lysed, and immunoblotted for β-arrestin1, tau, and actin. Representative blots are shown. (B) Quantification of tau. n = 4 independent experiments. #P < 0.0001. Unpaired t test. All data are presented as mean ± SEM. (C) DIV18 cortical primary neurons derived from PS19 P0 pups were transduced with control, β-arrestin1 or β-arrestin2, lysed and immunoblotted for β-arrestin1, tau, and actin.