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. 2021 Dec 2;5(3):e202101164. doi: 10.26508/lsa.202101164

Figure 5. Cu–albumin–induced structural and functional mitochondrial alterations.

Figure 5.

(A) Cu–albumin incubation causes membranous inclusions and unorganized/shortened cristae in mitochondria of EA.hy926 and U87MG cells. In the co-presence of ALXN1840, but not of DPA, these alterations are partially resolved (Scale bars 500 nm). (B) Respiratory control ratios (RCR), defined as routine to leak respiration (R/L) or electron transport system to leak respiration (E/L). Co-presence of ALXN1840, but not of DPA, significantly/markedly augments the Cu–albumin induced E/L ratio drop in EA.hy926 and U87MG cells, respectively (N = 4–7). Two-way ANOVA with Dunnett’s multiple comparisons test was used for statistical analysis. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.