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. 2021 Dec 6;17(12):e1009638. doi: 10.1371/journal.pcbi.1009638

Fig 11. RAR/RXR pathway is an example of WGD importance.

Fig 11

(A) In presence of Retinoid Acid (RA) the RAR/RXR complex recruits Nuclear CoActivators (NCOA), activating the transcription of the downstream gene. (B) In absence of RA the RAR/RXR complex recruits Nuclear CoRepressors (NCOR) instead, blocking the transcription of the downstream gene. (C) Protein-protein interactions among the genes involved in the RAR/RXR pathway, common interactions with other genes are not shown for clarity. Genes colored in the same way are WGD copies of a common ancestral gene.