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. 2021 Dec 2;12:782891. doi: 10.3389/fimmu.2021.782891

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Copyright © 2021 Cevey, Mascolo, Penas, Pieralisi, Sequeyra, Mirkin and Goren

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RAW 264.7 macrophages were treated with 15 µM of benznidazole (Bzl) for 30 minutes and then with 10 µg/mL of LPS. After 4 h, IL-6, TNF-α and IL-17A mRNA levels were analyzed by RT-qPCR and normalized against β-actin mRNA (A). After 24 h, Mannose Receptor (MR), TGF-β, VEGF-A (B), PPAR-α and PPAR-γ (C) mRNA levels were analyzed by RT-qPCR and normalized against β-actin mRNA. Results are expressed as the mean of 3 independent experiments (n=3, 5 replicates/treatment) ± SEM. *P < 0.05, **P < 0.001, ***P < 0.0001 vs. control cells; ^#P < 0.05, ^##P < 0.001, ^###P < 0.0001, ^####P < 0.00001 vs LPS-stimulated cells.