Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Dec 2;12:766082. doi: 10.3389/fphar.2021.766082

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2021 Cohn, Melnik, Huang, Teter, Chandra, Zhu, McIntire, John, Gylys and Bilousova.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Proteomic analysis of microglial EVs from normal/low pathology and late-stage AD cases. (A) Venn diagram representing microglial proteins differentially detected in NL and AD groups. (B) Volcano plot showing a degree of differential expression of proteins in NL and AD groups. Vertical red dotted lines separate proteins, which are two or more times less abundant in AD (far left segment) and two or more times more abundant in AD (far right segment). Horizontal red dotted line separates the top part of the plot containing dots representing proteins whose abundances are significantly different between NL and AD groups (p < 0.05) and the bottom part (no significant changes). Proteins that are significantly different between AD and NL groups are color-coded: two or more times more abundant in AD are presented in red, two or more times less abundant in green. (C) Heat map of proteins significantly up- and downregulated in AD compared to the NL group across seven evaluated human cases. (D) Immunoblotting of CD11b-IP samples with antibodies against ApoE and TREM2. Representative images are in the upper section and the composite data are in the lower section (*p < 0.05). (E) Gene ontology enrichment bioinformatic analysis of proteins two or more times less abundant in AD compared to NL. (F) Gene ontology enrichment bioinformatic analysis of proteins two or more times more abundant in AD compared to NL.