Table 3.
Scoring proposed by regulatory agencies for eye irritation tests after 21 days [51]
| Signs | Score | Observation during 21 days |
|---|---|---|
| corneal opacity (the area most dense taken for reading); no ulceration or opacity | 0 | 0 |
| scattered or diffuse areas of opacity (other than slight dulling of normal cluster); details of iris clearly visible | 0–1 | 0 |
| easily discernible translucent area; details of iris slightly obscured | 0–2 | 0 |
| opalescent areas; no details of iris visible, size of pupil barely discernible | 0–3 | 0 |
| opaque cornea; iris not discernible through the opacity | 0–4 | 0 |
| iritis; normal | 0 | 0 |
| deepened iris rugae and/or iris congestion or swelling, with circumcorneal injection | 0–1 | 0 |
| haemorrhage, gross destruction of iris or non‐reactivity to light | 0–2 | 0 |
| conjunctiva redness (palpebral and bulbar conjunctivae); blood vessels normal | 0 | 0 |
| some blood vessels definitely hyperaemia (injected) | 0–1 | 0 |
| diffuse Crimson colour; individual vessels not easily discernible | 0–2 | 0 |
| diffuse beefy red | 0–3 | 0 |
| total score | 0 | |