Green 2000.

Methods	Randomization and treatment allocation method: yes Blinding of outcome assessment: yes Blinding of participants: no Study period: not stated
Participants	Number: 60 enrolled Inclusion criteria: healthy infants (6 weeks to 20 months), elective surgery Exclusion criteria: cardiac and respiratory disease
Interventions	No pre‐medication. Tidal volume breathing technique, Ayre's T‐piece Group 1: 2% sevoflurane in 67% N2O Group 2: 8% sevoflurane in 67% N2O
Outcomes	Bradycardia Nodal rhythm Airway complication Hypoxia
Notes	Location: UK Setting: operating room Source of funding: not stated
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote: "Patients were allocated randomly to receive interventions using a computer‐generated random number allocation and close envelope technique"
Allocation concealment (selection bias)	Low risk	Quote: "Patients were allocated randomly to receive interventions using a computer‐generated random number allocation and close envelope technique"
Blinding (performance bias and detection bias) All outcomes	Low risk	Qoute: "...by an observer blinded to method of induction"
Incomplete outcome data (attrition bias) All outcomes	Low risk	No missing data.
Selective reporting (reporting bias)	Low risk	Study authors reported all planned outcomes