Singh 2014.

Methods	Randomization and treatment allocation method: yes Blinding of outcome assessment: no Blinding of participants: no Study period: not stated
Participants	Number: 100 enrolled Inclusion criteria: 1‐ to 8‐year‐old patients undergoing ophthalmological examination under anaesthesia Exclusion criteria: seizure disorder, craniofacial abnormalities/difficult airway, cardiopulmonary or neuromuscular defects, hepatic or renal insufficiency, expected difficult intravenous cannulation
Interventions	Midazolam 0.5 mg/kg orally about 30 minutes before induction of anaesthesia Group 1: incremental sevoflurane (increased by 1% every 3 breaths) in 50% N2O with fresh gas flow of 6 LPM Group 2: 8% sevoflurane with priming circuit in 50% N2O with 6 LPM
Outcomes	Time to loss of consciousness (loss of eyelash reflex and jaw relaxation) Time to intravenous cannulation and LMA insertion Liquid sevoflurane consumed during induction and LMA insertion Adverse events
Notes	Location: not stated Setting: operating room Source of funding: not stated
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Quote:"The patients were divided into 2 groups of 50 each using a computer‐generated table of random numbers"
Allocation concealment (selection bias)	Unclear risk	Information insufficient to permit judgement
Blinding (performance bias and detection bias) All outcomes	Unclear risk	Information insufficient to permit judgement
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	Information insufficient to permit judgement
Selective reporting (reporting bias)	Unclear risk	Quote: "The number of adverse events was also similar. The most common problem noted was temporary breath holding in both groups, which resolved spontaneously. One patient in the high‐concentration group experienced laryngospasm and was excluded from analysis because of change in the management plan"