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. 2021 Nov 17;17(2):92–101. doi: 10.17925/EE.2021.17.2.92

Table 1: Cardiovascular outcome trials on type 2 diabetes.

Trial acronym Trial name Clinical trial identifier
LEADER Liraglutide effect and action in diabetes: Evaluation of cardiovascular outcome results NCT01179048
SUSTAIN-6 Cardiovascular and other long-term outcomes with semaglutide in subjects with type 2 diabetes NCT01720446
HARMONY Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease NCT02465515
FIGHT14 Functional impact of GLP-1 for heart failure treatment NCT01800968
LIRA-RENAL12 Efficacy and safety of liraglutide versus placebo as add-on to glucose-lowering therapy in patients with type 2 diabetes and moderate renal impairment NCT01620489
SAVOR-TIMI 53 The saxagliptin assessment of vascular outcomes recorded in patients with diabetes mellitus [SAVOR]–thrombolysis in myocardial infarction [TIMI] 53 NCT01107886
TECOS Trial evaluating cardiovascular outcomes with sitagliptin NCT00790205
VERIFY Vildagliptin efficacy in combination with metformIn for early treatment of type 2 diabetes NCT01528254
EXAMINE Examination of cardiovascular outcomes with alogliptin versus standard of care NCT00968708
CANVAS Canagliflozin cardiovascular assessment study NCT01032629
EMPA-REG OUTCOME Empagliflozin cardiovascular outcome event trial NCT01131676
DECLARE-TIMI 58 Dapagliflozin effect on cardiovascular events–thrombolysis in myocardial infarction 58 NCT01730534
SCORED Sotagliflozin on cardiovascular and renal events in patients with type 2 diabetes and moderate renal impairment who are at cardiovascular risk NCT03315143
SOLOIST-WHF Sotagliflozin on cardiovascular events in patients with type 2 diabetes post worsening heart failure NCT03521934
VERTIS Evaluation of ertugliflozin efficacy and safety cardiovascular outcomes trial NCT01986881
UKPDS The UK prospective diabetes study ISRCTN75451837
ADVANCE Blood pressure and glucose lowering for the prevention of vascular disease in high risk patients with type 2 diabetes NCT00145925
ACCORD Action to control cardiovascular risk in diabetes NCT00000620
VADT Veterans Affairs diabetes trial NCT00032487
ELIXA Evaluation of lixisenatide in acute coronary syndrome NCT01147250
EXSCEL Exenatide study of cardiovascular event lowering NCT01144338
PIONEER 6 Peptide innovation for early diabetes treatment NCT02692716
REWIND Researching cardiovascular events with a weekly incretin in diabetes NCT01394952
CARMELINA Cardiovascular and renal microvascular outcome study with linagliptin NCT01897532