Table 2.
Silk‐based 3D structures reviewed, cell types used and potential applications
| Biomaterial | Synthesis methods | Cell type used | Potential applications | References |
|---|---|---|---|---|
| silk fibroin MCs | droplet production | murine fibroblasts L‐929 | wound healing | [63] |
| co‐precipitation | C2C12 cell line | drug delivery system for TE applications | [65, 66] | |
| silk fibroin/alginate MCs | droplet production followed by fibroin coating | hASCs | cell delivery for advanced therapy and regenerative medicine of bone and cartilage diseases or defects | [28, 58, 74] |
| hBMSCs | ||||
| silk fibroin/gelatin MCs | freezing thawing | 3T3 murine fibroblast | wound healing | [59, 77] |
| mixing | rMSC | bone TE | [17] | |
| silk fibroin/calcium phosphate MCs | freezing thawing | MG‐63 | bone‐TE | [29, 81] |
| MSCs | ||||
| silk fibroin/pullulan MCs | water‐in‐oil emulsion | SaoS‐2 cell line | bone‐TE | [60] |
| silk fibroin/chitosan microparticles | spray‐drying | rMSCs | cardiac patches | [93] |
| — | drug delivery systems | [62, 89] | ||
| emulsification | — | [90, 91, 92] | ||
| silk fibroin/Collagen microparticles | droplet production followed by coating | MG 63 osteoblast‐like cell line | bone‐TE (load‐bearing osteo‐regenerative applications). | [61] |
| silk organoids | freeze‐drying | iPSCs | regenerative medicine – kidney tissue | [97] |