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Tumorigenic role of box C/D snoRNAs
The oncosnoRNAs define a large family of non-coding small nucleolar RNAs that may act as proto-oncogenes (in red, increased levels in cancer) or tumour suppressors (in green, reduced levels). In the centre, structure of a typical box C/D snoRNA (black) base-paired to its substrate (orange). The methylated position on the substrate is located 5 nucleotides away from box D (or box D') on the snoRNA.
