Table 2.
Box C/D snoRNAs involved in oncogenic pathways
| SnoRNA name | Cancer Type | Expression in cancer | Associated cellular process | Ref. |
|---|---|---|---|---|
| U3 or U8 | BCa, NSCLC | up | Cell cycle arrest and apoptosis | [53] |
| SNORD10 | GC | up | Stimulates cell growth | [100] |
| SNORD28 | BCa | up | Cell proliferation | [102] |
| SNORD46 | pan-cancer | up | Stimulates cell proliferation, migration, and invasion | [50] |
| SNORD47 | GBM | down | Promotes invasion via epithelial-mesenchymal transition | [88] |
| SNORD50A SNORD50B | 12 most common cancers | down | Cell growth by direct binding to K-Ras | [87,128] |
| SNORD72 | HCC | up | Proliferation and invasion | [98] |
| SNORD76 | GBM, HCC | down/up | Cell cycle block/Invasion through epithelial-mesenchymal transition | [89,90] |
| SNORD105b | GC | up | Promotes cellular proliferation, migration and invasion via ALDOA/c-Myc pathway | [101] |
| SNORD112-114 cluster | APL | up | Promotes cell growth by Rb/p16 cell cycle regulation | [94] |
| SNORD113‐1 | HCC | down | Cell growth | [140] |
| SNORD114-1 | AML | up | Cell cycle progression through G0/G1 to S phase transition | [92] |
| SNORD126 | HCC, CRC | up | Enhances cell growth by activating the PI3K-AKT pathway via FGFR2 | [96,97] |
| SNORD14D SNORD35A | AML | up | Stimulate self-renewal and cell proliferation | [91] |
| SNORD19.2 SNORD86 SNORD77 | CRC | up | Metastatic spread | [99] |
| SNORD114-10 SNORD114-2 SNORD114-11 | OC | down | Metastatic spread | [95] |
AML, Acute myeloid leukaemia; APL, Acute promyelocytic leukaemia; HCC, Hepatocellular carcinoma; CRC, Colorectal cancer; GBM, Glioblastoma; GC, Gastric cancer; BCa, Breast cancer; NSCLC, Non-small cell lung cancer; OC, Ovarian cancer.