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. 2021 Aug 23;18(Suppl 1):19–30. doi: 10.1080/15476286.2021.1969113

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© 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 3. — A model for crosstalk of m⁶A and other mRNA modifications at mRNA

Some readers show ability to recognize more than one chemical mark in mRNA (on the left). This can have different consequences (on the right), such as: A. Competitive binding. B. Counter regulation by modifications. In this way RNA-modification-reader complex may act as a recruitment platform for other factors and/or can facilitate deposition/recognition of other modifications in the RNA molecule. C. Cooperative reader recruitment: Different modification at the same template act synergistically in cooperative manner to increase or manifest the load of common reader proteins at given mRNA template. Herein multi-readerassembly may facilitate events essential for mRNP packaging, remodelling, export or surveillance.