Yoon 2017.

Study characteristics
Patient Sampling	Method of sampling: selected Included conditions: "large restorations, and extensive caries involving more than half of the proximal surfaces were excluded" Teeth: permanent premolars Sealants: not reported Surface: approximal
Patient characteristics and setting	Age: not reported Sex: not reported Ethnicity: not reported Country: South Korea Setting: extracted teeth Number of participants/teeth/sites: 102 teeth Prevalence: any caries 0.63, dentine level not reported
Index tests	Category of test: DIAGNOdent and QLF‐D (QLF‐D Biluminator 2, Inspektor Research Systems) Sequence of test(s): radiograph (reference standard) followed by QLF and DIAGNOdent Examiner training and calibration: "performed by a single skilled examiner who had sufficient training" Teeth cleaning prior to examination: "distilled water to remove soft tissue and plaque" Tooth drying prior to examination: air‐dried for 5 seconds Threshold applied: DIAGNOdent: "value was 10 or higher" QLF: "fluorescence loss (ΔF) was measured"....."caries was diagnosed when the maximum QLF "diagnosed as caries when the fluorescence loss was lower than ‐13.8" Device specifics: DIAGNOdent: probe A QLF: "shutter speed of 1/15 s, aperture value of 8.0, ISO speed of 1600, white balance as manual (white light) or daylight (blue light)"
Target condition and reference standard(s)	Category: bitewing radiograph Sequence of index test and reference standard: prior to index tests Training of examiner: yes but not clearly reported Blinding to index test: done prior to index tests Multiple tests: no Site selection: not reported Target condition: sound, enamel or dentine caries
Flow and timing	Participants with index test but no reference standard: 0 Participants with reference standard but no index test: 0 Time interval between tests: minimal Participants receiving both tests but excluded from results: 0
Comparative
Notes
Methodological quality
Item	Authors' judgement	Risk of bias	Applicability concerns
DOMAIN 1: Patient Selection
Was a consecutive or random sample of patients enrolled?	No
Was a case‐control design avoided?	Yes
Did the study avoid inappropriate exclusions?	Yes
Could the selection of patients have introduced bias?		High risk
Are there concerns that the included patients and setting do not match the review question?			High
DOMAIN 2: Index Test (All)
Were the index test results interpreted without knowledge of the results of the reference standard?	No
If a threshold was used, was it pre‐specified?	Yes
If multiple tests were applied were different examiners used for each (in vivo)?	No
Could the conduct or interpretation of the index test have introduced bias?		Low risk
Are there concerns that the index test, its conduct, or interpretation differ from the review question?			Low concern
DOMAIN 2: Index Test (Green fluorescence)
Were the index test results interpreted without knowledge of the results of the reference standard?	No
If a threshold was used, was it pre‐specified?	Yes
If multiple tests were applied were different examiners used for each (in vivo)?	No
Could the conduct or interpretation of the index test have introduced bias?		Low risk
Are there concerns that the index test, its conduct, or interpretation differ from the review question?			Low concern
DOMAIN 2: Index Test (Blue fluorescence)
DOMAIN 2: Index Test (Red fluorescence)
DOMAIN 3: Reference Standard
Is the reference standards likely to correctly classify the target condition?	No
Were the reference standard results interpreted without knowledge of the results of the index tests?	Yes
Could the reference standard, its conduct, or its interpretation have introduced bias?		High risk
Are there concerns that the target condition as defined by the reference standard does not match the question?			Low concern
DOMAIN 4: Flow and Timing
Was there an appropriate interval between index test and reference standard?	Yes
Did all patients receive the same reference standard?	Yes
Were all patients included in the analysis?	Yes
Could the patient flow have introduced bias?		Low risk