Table 2.
Genotypes and allele frequencies of vitamin D metabolic pathway genes in RA patients and controls.
| SNP | Analyze model | RA (n = 477) | Control (n = 496) | P value | OR (95% CI) | |
|---|---|---|---|---|---|---|
| CYP2R1 | ||||||
| rs7936142 | Genotypes | TT | 6 (1.26) | 7 (1.41) | 0.849 | 1.112 (0.370,3.341) |
| AT | 102 (21.38) | 102 (20.56) | 0.763 | 0.953 (0.700,1.299) | ||
| AA | 369 (77.36) | 387 (78.02) | Reference | |||
| Alleles | T | 114 (11.95) | 116 (11.69) | 0.861 | 0.976 (0.741,1.285) | |
| A | 840 (88.05) | 876 (88.31) | Reference | |||
| Dominant model | AA | 369 (77.36) | 387 (78.02) | 0.803 | 1.039 (0.768,1.405) | |
| AT+TT | 108 (22.64) | 109 (21.98) | Reference | |||
| Recessive model | TT | 6 (1.26) | 7 (1.41) | 0.835 | 1.124 (0.375,3.368) | |
| AA+AT | 471 (98.74) | 489 (98.59) | Reference | |||
| rs12794714 | Genotypes | AA | 54 (11.32) | 66 (13.31) | 0.280 | 1.254 (0.832,1.891) |
| GA | 225 (47.17) | 237 (47.78) | 0.573 | 1.081 (0.825,1.415) | ||
| GG | 198 (41.51) | 193 (38.91) | Reference | |||
| Alleles | A | 333 (34.91) | 369 (37.20) | 0.293 | 1.105 (0.918,1.329) | |
| G | 621 (65.09) | 623 (62.80) | Reference | |||
| Dominant model | GG | 198 (41.51) | 193 (38.91) | 0.409 | 0.898 (0.695,1.160) | |
| AA+GA | 279 (58.49) | 303 (61.09) | Reference | |||
| Recessive model | AA | 54 (11.32) | 66 (13.31) | 0.347 | 1.202 (0.819,1.765) | |
| GG+GA | 423 (88.68) | 430 (86.69) | Reference | |||
| rs1993116 | Genotypes | AA | 69 (14.47) | 68 (13.71) | 0.289 | 0.810 (0.548,1.196) |
| GA | 233 (48.85) | 215 (43.35) | 0.047 | 0.758 (0.577,0.996) | ||
| GG | 175 (36.69) | 213 (42.94) | Reference | |||
| Alleles | A | 371 (38.89) | 351 (35.38) | 0.110 | 0.860 (0.716,1.034) | |
| G | 583 (61.11) | 641 (64.62) | Reference | |||
| Dominant model | GG | 175 (36.69) | 213 (42.94) | 0.047 | 1.299 (1.004,1.680) | |
| AA+GA | 302 (63.31) | 283 (57.06) | Reference | |||
| Recessive model | AA | 69 (14.47) | 68 (13.71) | 0.735 | 0.939 (0.655,1.348) | |
| GG+GA | 408 (85.53) | 428 (86.29) | Reference | |||
| CYP24A1 | ||||||
| rs2296239 | Genotypes | CC | 62 (13.00) | 63 (12.70) | 0.897 | 0.974 (0.649,1.460) |
| CT | 232 (48.64) | 242 (48.79) | 0.997 | 0.999 (0.762,1.311) | ||
| TT | 183 (38.36) | 191 (38.51) | Reference | |||
| Alleles | C | 356 (37.32) | 368 (37.10) | 0.920 | 0.991 (0.824,1.191) | |
| T | 598 (62.68) | 624 (62.90) | Reference | |||
| Dominant model | TT | 183 (38.36) | 191 (38.51) | 0.963 | 1.006 (0.777,1.303) | |
| CC+CT | 294 (61.64) | 305 (61.49) | Reference | |||
| Recessive model | CC | 62 (13.00) | 63 (12.70) | 0.890 | 0.974 (0.669,1.418) | |
| TT+CT | 415 (87.00) | 433 (87.30) | Reference | |||
| rs2296241 | Genotypes | AA | 94 (19.71) | 87 (17.54) | 0.394 | 0.853 (0.593,1.229) |
| GA | 229 (48.01) | 242 (48.79) | 0.858 | 0.975 (0.734,1.294) | ||
| GG | 154 (32.29) | 167 (36.67) | Reference | |||
| Alleles | A | 417 (43.71) | 416 (41.94) | 0.429 | 0.930 (0.777,1.113) | |
| G | 537 (56.29) | 576 (58.06) | Reference | |||
| Dominant model | GG | 154 (32.29) | 167 (33.67) | 0.646 | 1.065 (0.815,1.391) | |
| AA+GA | 323 (67.71) | 329 (66.33) | Reference | |||
| Recessive model | AA | 94 (19.71) | 87 (17.54) | 0.386 | 0.867 (0.627,1.197) | |
| GG+GA | 383 (80.29) | 409 (82.46) | Reference | |||
| rs2762934 | Genotypes | AA | 5 (1.05) | 7 (1.41) | 0.644 | 1.314 (0.413,4.176) |
| GA | 106 (22.22) | 99 (19.96) | 0.403 | 0.876 (0.644,1.194) | ||
| GG | 366 (76.73) | 390 (78.63) | Reference | |||
| Alleles | A | 116 (12.16) | 113 (11.39) | 0.599 | 0.929 (0.705,1.224) | |
| G | 838 (87.84) | 879 (88.61) | Reference | |||
| Dominant model | GG | 366 (76.73) | 390 (78.63) | 0.477 | 1.116 (0.825,1.509) | |
| AA+GA | 111 (23.27) | 106 (21.37) | Reference | |||
| Recessive model | AA | 5 (1.05) | 7 (1.41) | 0.609 | 1.351 (0.426,4.287) | |
| GG+GA | 472 (98.05) | 489 (98.59) | Reference | |||
| rs6068816 | Genotypes | TT | 66 (13.84) | 73 (14.72) | 0.304 | 1.153 (0.879,1.513) |
| CT | 204 (42.77) | 225 (45.36) | 0.460 | 1.156 (0.786,1.701) | ||
| CC | 207 (43.40) | 198 (39.92) | Reference | |||
| Alleles | T | 336 (35.22) | 371 (37.40) | 0.318 | 1.099 (0.913,1.322) | |
| C | 618 (64.78) | 621 (62.60) | Reference | |||
| Dominant model | CC | 207 (43.40) | 198 (39.92) | 0.271 | 0.867 (0.672,1.118) | |
| TT+CT | 270 (56.60) | 298 (60.08) | Reference | |||
| Recessive model | TT | 66 (13.84) | 73 (14.72) | 0.695 | 1.075 (0.750,1.540) | |
| CC+CT | 411 (86.16) | 423 (85.28) | Reference | |||
| VDR | ||||||
| rs3847987 | Genotypes | AA | 26 (4.45) | 25 (5.04) | 0.818 | 0.935 (0.527,1.658) |
| CA | 168 (35.22) | 180 (36.29) | 0.762 | 1.042 (0.798,1.360) | ||
| CC | 283 (59.33) | 291 (58.67) | Reference | |||
| Alleles | A | 220 (23.06) | 230 (23.19) | 0.948 | 1.007 (0.816,1.243) | |
| C | 734 (76.94) | 762 (76.81) | Reference | |||
| Dominant model | CC | 283 (59.33) | 291 (58.67) | 0.834 | 0.973 (0.754,1.256) | |
| AA+CA | 194 (40.67) | 205 (41.33) | Reference | |||
| Recessive model | AA | 26 (5.45) | 25 (5.04) | 0.774 | 0.921 (0.524,1.618) | |
| CC+CA | 451 (94.55) | 471 (94.96) | Reference | |||
| rs11574129 | Genotypes | GG | 19 (3.98) | 18 (3.63) | 0.866 | 0.944 (0.487,1.832) |
| GA | 132 (27.67) | 151 (30.44) | 0.357 | 1.140 (0.862,1.508) | ||
| AA | 326 (68.34) | 327 (65.93) | Reference | |||
| Alleles | G | 170 (17.82) | 187 (18.85) | 0.557 | 1.071 (0.851,1.348) | |
| A | 784 (82.18) | 805 (81.15) | Reference | |||
| Dominant model | AA | 326 (68.34) | 327 (65.93) | 0.423 | 0.896 (0.686,1.171) | |
| GG+GA | 151 (31.66) | 169 (34.07) | Reference | |||
| Recessive model | GG | 19 (3.98) | 18 (3.63) | 0.773 | 0.908 (0.470,1.752) | |
| AA+GA | 458 (96.02) | 478 (96.37) | Reference | |||
| CYP27B1 | ||||||
| rs4646536 | Genotypes | AA | 72 (15.09) | 64 (12.90) | 0.085 | 0.710 (0.480,1.048) |
| GA | 227 (47.59) | 209 (42.14) | 0.027 | 0.735 (0.560,0.965) | ||
| GG | 178 (37.32) | 223 (44.96) | Reference | |||
| Alleles | A | 371 (38.89) | 337 (33.97) | 0.024 | 0.809 (0.672,0.973) | |
| G | 583 (61.11) | 655 (66.03) | Reference | |||
| Dominant model | GG | 178 (37.32) | 223 (44.96) | 0.016 | 1.372 (1.062,1.773) | |
| AA+GA | 299 (62.68) | 273 (55.04) | Reference | |||
| Recessive model | AA | 72 (15.09) | 64 (12.90) | 0.325 | 0.833 (0.580.1.198) | |
| GG+GA | 405 (84.91) | 432 (87.10) | Reference | |||
Bold value means P < 0.05.