Table 3.

Association between vitamin D metabolic pathway gene polymorphisms and anti-CCP, RF in RA patients.

SNPs	Allele	Clinical features	Group	Genotypes			P value	Alleles		P value
	(M/m)			MM	Mm	mm		M	m
CYP2R1
rs7936142	A/T	anti-CCP	Positive	274	72	5	0.569	620	82	0.613
			Negative	62	16	0		140	16
		RF	Positive	291	81	6	0.518	663	93	0.473
			Negative	62	16	0		140	16
rs12794714	G/A	anti-CCP	Positive	143	172	36	0.082	458	244	0.185
			Negative	30	33	15		93	63
		RF	Positive	156	178	44	0.888	490	266	0.636
			Negative	30	38	10		98	58
rs1993116	G/A	anti-CCP	Positive	124	173	54	0.762	421	281	0.510
			Negative	31	36	11		98	58
		RF	Positive	144	177	57	0.139	465	291	0.770
			Negative	24	46	8		94	62
CYP24A1
rs2296239	T/C	anti-CCP	Positive	133	176	42	0.779	442	260	0.973
			Negative	31	36	11		98	58
		RF	Positive	146	186	46	0.945	478	278	0.924
			Negative	29	40	9		98	58
rs2296241	G/A	anti-CCP	Positive	106	175	70	0.157	387	315	0.189
			Negative	32	31	15		95	61
		RF	Positive	122	179	77	0.599	423	333	0.401
			Negative	27	39	12		93	63
rs2762934	G/A	anti-CCP	Positive	267	80	4	0.789	614	88	0.572
			Negative	62	15	1		139	17
		RF	Positive	287	87	4	0.614	661	95	0.422
			Negative	63	14	1		140	16
rs6068816	C/T	anti-CCP	Positive	151	152	48	0.593	454	248	0.532
			Negative	38	29	11		105	51
		RF	Positive	167	162	49	0.506	496	260	0.414
			Negative	33	31	14		97	59
VDR
rs3847987	C/A	anti-CCP	Positive	211	123	17	0.353	545	157	0.165
			Negative	40	33	5		113	43
		RF	Positive	228	131	19	0.216	587	169	0.082
			Negative	39	33	6		111	45
rs11574129	A/G	anti-CCP	Positive	239	100	12	0.897	578	124	0.645
			Negative	51	24	3		126	30
		RF	Positive	260	104	14	0.675	624	132	0.366
			Negative	50	24	4		124	32
CYP27B1
rs4646536	G/A	anti-CCP	Positive	132	162	57	0.528	426	276	0.621
			Negative	29	40	9		98	58
		RF	Positive	143	178	57	0.949	464	292	0.794
			Negative	28	38	12		94	62