Table 4.
Haplotype analysis of CYP2R1, CYP24A1, VDR in RA patients and controls.
| Haplotype | RA [n(%)] | Controls [n(%)] | P value | OR (95% CI) |
|---|---|---|---|---|
| CYP2R1 rs7936142-rs12794714-rs1993116 | ||||
| AAG | 332.99 (34.9) | 368.99 (37.2) | 0.293 | 0.905 (0.752,1.090) |
| AGA | 370.99 (38.9) | 350.99 (35.4) | 0.109 | 1.162 (0.967,1.397) |
| AGG | 250.01 (26.2) | 272.01 (27.4) | 0.545 | 0.940 (0.769,1.149) |
| CYP24A1 rs2296239-rs2296241-rs2762934-rs6068816 | ||||
| CAAC | 85.12 (8.9) | 76.67 (7.7) | 0.387 | 1.153 (0.835,1.593) |
| CAGC | 74.28 (7.8) | 85.27 (8.6) | 0.457 | 0.884 (0.638,1.224) |
| CGGC | 95.08 (10.0) | 102.59 (10.3) | 0.706 | 0.945 (0.703,1.270) |
| CGGT | 60.57 (6.3) | 60.03 (6.1) | 0.846 | 1.037 (0.717,1.501) |
| TAGC | 224.08 (23.5) | 218.03 (2.5) | 0.525 | 1.072 (0.865,1.328) |
| TGGC | 128.85 (13.5) | 124.54 (12.6) | 0.610 | 1.071 (0.822,1.397) |
| TGGT | 232.19 (24.3) | 256.14 (25.8) | 0.348 | 0.905 (0.736,1.114) |
| VDR rs3847987- rs11574129 | ||||
| AA | 50.00 (5.2) | 40.00 (4.3) | 0.348 | 1.221 (0.804,1.854) |
| AG | 170.00 (17.8) | 187.00 (18.9) | 0.557 | 0.933 (0.742,1.175) |
| CA | 734.00 (76.9) | 762.00 (76.8) | 0.948 | 1.007 (0.816,1.243) |
Frequency < 0.03 in both controls and RA patients has been dropped.