Table 6.

The association between CYP24A1, CYP27B1, CYP2R1, VDR methylation levels and antibody, drug treatment in RA patients.

Group	N	CYP2R1 methylation level	P value	CYP24A1 methylation level	P value	VDR methylation level	P value	CYP27B1 methylation level	P value
										Antibody
Anti-CCP			0.460		0.930		0.815		0.414
+	88	0.0073 (0.0069,0.0078)		0.0399 (0.0351,0.0451)		0.0189 (0.0171,0.0213)		0.0310 (0.0264,0.0387)
−	14	0.0072 (0.0065,0.0076)		0.0393 (0.0350,0.0471)		0.0193 (0.0168,0.0250)		0.0345 (0.0271,0.0402)
RF			0.266		0.556		0.504		0.770
+	99	0.0072 (0.0068,0.0076)		0.0396 (0.0348,0.0451)		0.0186 (0.0170,0.0212)		0.0312 (0.0263,0.0385)
−	17	0.0075 (0.0070,0.0078)		0.0386 (0.0340,0.0454)		0.0174 (0.0167,0.0209)		0.0305 (0.0268,0.0354)
Drug treatment
glucocorticoid			0.794		0.859		0.067		0.924
+	68	0.0072 (0.0067,0.0077)		0.0305 (0.0261,0.0382)		0.0177 (0.0164,0.0207)		0.0305 (0.0261,0.0382)
−	40	0.0072 (0.0068,0.0076)		0.0391 (0.0348,0.0450)		0.0192 (0.0177,0.0217)		0.0311 (0.0267,0.0362)
Methotrexate			0.300		0.877		0.690		0.877
+	38	0.0072 (0.0065,0.0075)		0.0390 (0.0347,0.0444)		0.0187 (0.0167,0.0203)		0.0300 (0.0262,0.0370)
−	70	0.0072 (0.0068,0.0078)		0.0394 (0.0345,0.0428)		0.0184 (0.0172,0.0212)		0.0309 (0.0266,0.0374)