Table 8.

Association between vitamin D metabolic pathway gene polymorphisms with their methylation levels in RA patients.

CYP2R1 SNP	Genotype	Number	CYP2R1 methylation level	P value
rs7936142	TT	1	0.0069	0.528
	AT	27	0.0072 (0.0069,0.0079)
	AA	94	0.0072 (0.0068,0.0076)
rs12794714	AA	12	0.0074 (0.0068,0.0079)	0.772
	GA	53	0.0072 (0.0068,0.0078)
	GG	57	0.0072 (0.0069,0.0076)
rs1993116	AA	19	0.0071 (0.0068,0.0075)	0.602
	GA	67	0.0072 (0.0068,0.0077)
	GG	36	0.0073 (0.0069,0.0078)
CYP24A1 SNP	Genotype	Number	CYP24A1 methylation level	P value
rs2296239	CC	18	0.0363 (0.0318,0.0475)	0.619
	CT	55	0.0382 (0.0347,0.0447)
	TT	49	0.0396 (0.0355,0.0451)
rs2296241	AA	20	0.0414 (0.0354,0.0457)	0.393
	GA	62	0.0381 (0.0334,0.0433)
	GG	40	0.0412 (0.0350,0.0464)
rs2762934	AA	2	0.0504 (0.0429,0.0579)	0.290
	GA	25	0.0377 (0.0325,0.0479)
	GG	95	0.0392 (0.0348,0.0442)
rs6068816	TT	18	0.0405 (0.0360,0.0474)	0.409
	CT	52	0.0387 (0.0337,0.0438)
	CC	52	0.0396 (0.0355,0.0462)
VDR SNP	Genotype	Number	VDR methylation level	P value
rs3847987	AA	6	0.0173 (0.0146,0.0197)	0.132
	CA	41	0.0198 (0.0173,0.0221)
	CC	75	0.0181 (0.0172,0.0202)
rs11574129	GG	6	0.0173 (0.0146,0.0197)	0.060
	GA	34	0.0198 (0.0175,0.0225)
	AA	82	0.0181 (0.0170,0.0203)
CYP27B1 SNP	Genotype	Number	CYP27B1 methylation level	P value
rs4646536	AA	14	0.0314 (0.0267,0.0384)	0.647
	GA	57	0.0311 (0.0268,0.0372)
	GG	51	0.0294 (0.0256,0.0372)

Median (interquartile range).