Fig. 4.
Induction of neutralizing antibody against SARS-CoV-2 by AdCoV2 vaccines. BALB/c mice were immunized with 1 × 107 pfu Ad-LacZ (N = 4), AdCoV2-S (N = 5), or AdCoV2-SdTM (N = 5) via i.n. or AdCoV2-S (N = 5) via s.c. at 14-day intervals. Sera collected from AdCoV vaccine-immunized BALB/c mice at 14 days (A), 1 month (B), and 3 months (C) post-immunization were applied to the neutralizing assay which was described in the Materials and Methods. N represents as numbers of mice per group. The experimental protocol was followed for the regulation of the RG-3 level during laboratory operation.