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. 2021 Dec 17;40(4):574–586. doi: 10.1016/j.vaccine.2021.12.024

Fig. 7.

Fig. 7

AdCoV2 vaccines protect animals from SARS-CoV-2 infection. Four hamsters per group were preimmunized twice i.n. with 3 × 107 pfu Ad-LacZ i.n., AdCoV2-S i.n., AdCoV2-S s.c., or AdCoV2-SdTM i.n. over a 14-day interval and then infected i.n. with 1 × 105 pfu of live SARS-CoV-2 1 month after the second vaccine shot. (A) On days 3 and (B) 6 post-infection, the hamsters were sacrificed and the lung tissues were homogenized for the TCID50 assay. The lowest limitation of detection for TCID50 assay was 1 × 101 TCID50/mL. (C) The body weight of AdCoV2-immunized hamsters followed by SARS-CoV-2 challenge was recorded. The results from 2 independent experiments (Exp. 1 and 2) were presented separately. When Ad-LacZ i.n. compares with AdCoV2-S i.n., the symbols * are used to indicate P < 0.05. When Ad-LacZ i.n. compares with AdCoV2-SdTM i.n. and AdCoV2-S s.c., the symbols # are used to indicate P < 0.05.