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. 2021 Feb 23;73(12):2166–2174. doi: 10.1093/cid/ciab168

Table 6.

Final Hazard Ratio Estimates and 95% Confidence Intervals (CI) Based on Multivariate Cox Models for Recurrent Events Estimating Risk Factors Associated With Repeated Occurrence of Ebola Virus Disease Sequelae After Ebola Treatment Center Discharge

Abdominala sequelae Neurologicalb sequelae Ocularc sequelae Musculoskeletald sequelae Generale sequelae
Symptoms of the acute phase HR (95% CI) P value HR (95% CI) P value HR (95% CI) P value HR (95% CI) P value HR (95% CI) P value
Sex (male) 1.24 (0.58–2.61) .581 1.28 (0.51–3.21) .600 1.09 (0.60–1.97) .781 0.62 (0.32–1.20) .156 0.71 (0.25–1.95) .503
Age (Linear Trend) 1.06 (0.89–1.25) .515 1.61 (0.68–3.81) .280 1.12 (1.01–1.27) .045 1.15 (1.05–1.26) .002 1.27 (1.00–1.62) .048
Age2 (QuadraticTrend) 0.99 (0.99–1.01) .602 0.71 (0.46–1.11) .140 0.99 (0.99–1.00) .117 0.99 (0.99–1.00) .013 0.99 (0.99–1.00) .099
General 0.32 (0.11–0.94) .038 1.12 (0.35–3.62) .840 0.34 (0.18–0.64) .003 0.60 (0.32–1.12) .110 0.56 (0.21–1.50) .250
Hemorrhage 0.81 (0.32–2.02) .650 0.55 (0.19–1.59) .270 2.70 (1.31–5.60) .007 1.91 (1.02–4.06) .045 0.91 (0.27–3.06) .888
Abdominala 1.70 (0.67–4.28) .260 2.00 (0.64–6.27) .240 1.27 (0.62–2.62) .509 2.21 (1.06–4.58) .033 1.84 (0.52–6.53) .343
Myalgia 1.92 (0.80–4.61) .144 0.83 (0.32–2.13) .700 0.96 (0.46–1.97) .902 0.68 (0.32–1.40) .294 5.04 (1.52–16.75) .008
Neurologicalb 2.28 (0.75–6.91) .143 1.39 (0.39–4.99) .610 2.63 (1.15–6.01) .021 1.07 (0.47–2.43) .871 0.34 (0.10–0.98) .049

Recurrent events refer to events of interest experienced repeatedly by a given individual.

Abbreviation: HR, hazard ratio.

aAbdominal = abdominal or pelvic pain, gastritis.

aNeurological = headache, dizziness and other (neurosensitive disorders, neuromotor disorders, behavioral problems).

aOcular = conjunctivitis, iridocyclitis, cataract, glaucoma, vision problems, ocular pain.

aMusculoskeletal = neck pain, back pain, joint pain, myalgia.

aGeneral = fever, fatigue, anorexia.