Table 2.

Production of isoprenoids by methylotrophic organisms.

Organism	Feedstock	Product	Titer	Ref.
Methylomonas sp. 16a	Methane	astaxanthin	2.4mg/g CDW	Ye et al., 2007
P. pastoris	Methanol**	(+)-nootkanone	208mg/L	Wriessnegger et al., 2014
P. pastoris	Methanol**	(+)-valencene	136mg/L
M. extorquens	Methanol	a-humulene	1.65g/L	Sonntag et al., 2015
P. pastoris	Methanol**	(+)-ambrein	105mg/L	Moser et al., 2018
P. pastoris	Methanol**	squalene	58mg/L
P. pastoris	Methanol**	lycopene	714mg/L	Zhang et al., 2020
M. alcaliphilum	Methane	α-humulene	0.75mg/g CDW	Nguyen et al., 2020
M. acetivorans	Methanol*	isoprene	0.954mM/L	Aldridge et al., 2021
M. barkeri	Methanol*	isoprene	36.0μM/L

^*Complex medium;

^**Carbon sources switched from glycerol to methanol in fed-batch fermentation.