Figure 5.

In vivo ¹⁸F-MK-6240 SUVR and post-mortem tau neuropathology in two patients with Alzheimer’s disease dementia. ¹⁸F-MK-6240 SUVR images acquired prior to the patients’ deaths (left), immunohistochemistry panels with AT8 staining (middle) and plots (right) with ¹⁸F-MK-6240 SUVR. AT8 staining density of neurofibrillary tangles (top) and the combination of neuropil threads and dystrophic neurites surrounding amyloid-β plaques (bottom). (A) Patient AA (MMSE = 12, CDR = 1, male, 85 years- old, late-onset sporadic Alzheimer’s disease) had an ¹⁸F-MK-6240 scan 12 months prior to death. Immunohistochemistry showed relevant tau tangles pathology in the hippocampus (Braak II), amygdala (Braak III), cingulate and inferior parietal (Braak IV) and superior temporal (Braak V) cortices but not in the calcarine cortex (Braak VI). Patient AA was classified as Braak stage V using both PET and post-mortem data. (B) Patient NA (MMSE = 12, CDR = 1, female, 63 years old, early-onset sporadic Alzheimer’s disease) had an ¹⁸F-MK-6240 scan 22 months prior to death. Immunohistochemistry showed tau tangles pathology across the brain cortex. Patient AA was classified as Braak stage VI using PET and post-mortem data.