Table 1.
Demographics and key characteristics of the population
| Characteristic | CU Aβ− | CU Aβ+ | MCI Aβ+ | AD Aβ+ | P-value |
|---|---|---|---|---|---|
| Number | 65 | 22 | 21 | 17 | |
| Age, years, mean (SD) | 70.7 (6.5) | 72.8 (6.2)# | 74 (5.4)# | 68 (7.4) | 0.008 |
| Male, number (%) | 22 (34) | 6 (28) | 15 (71)*,† | 10 (59) | 0.004 |
| Education, years, mean (SD) | 15.3 (3.7) | 15 (3.9) | 14.4 (3.8) | 15.2 (3.8) | 0.840 |
| MMSE score, mean (SD) | 29.1 (1.3) | 28.8 (1.3)# | 26.8 (3.7)*,# | 20.7 (6.5)* | <0.001 |
| APOE ε4, number (%) | 20 (31) | 6 (27) | 9 (43) | 7 (41) | 0.599 |
| Amyloid-β PET, SUVR, mean (SD) | 1.24 (0.08) | 1.82 (0.32)*,# | 2.02 (0.5)*,# | 2.58 (0.43)* | <0.001 |
| Scan interval, years, mean (SD) | 1.12 (0.2) | 1.08 (0.2) | 1.25 (0.3) | 1.31 (0.5) | 0.054 |
The P-values indicate the results of the ANOVA testing significant differences between groups for continuous variables, except for sex and APOE ε4, where a contingency chi-square was performed. Bonferroni’s post hoc analysis provided significant differences between groups.
*
P < 0.05 compared with CU Aβ−.
†
P < 0.05 compared with CU Aβ+.
#
P < 0.05 compared with AD Aβ+.