Table 2.
Univariate and multivariate analysis of the association between clinical characteristics and overall survival of colorectal-cancer patients
| Characteristic | Univariate analysis |
Multivariate analysis |
||
|---|---|---|---|---|
| HR (95% CI) | P-value | HR (95% CI) | P-value | |
| Sex | <0.001 | 0.014 | ||
| Male | 1.00 | 1.00 | ||
| Female | 0.86 (0.80–0.92) | 0.92 (0.86–0.98) | ||
| Age | <0.001 | <0.001 | ||
| <60 years | 1.00 | 1.00 | ||
| ≥60 years | 1.46 (1.36–1.57) | 1.87 (1.74–2.01) | ||
| Family history | 0.003 | <0.001 | ||
| No | 1.00 | 1.00 | ||
| Yes | 0.79 (0.68–0.92) | 0.73 (0.63–0.85) | ||
| Location | 0.010 | <0.001 | ||
| Right-sided colon | 1.00 | 1.00 | ||
| Left-sided colon | 0.87 (0.79–0.95) | 0.93 (0.84–1.02) | ||
| Rectum | 0.92 (0.84–0.99) | 1.24 (1.14–1.35) | ||
| Differentiation status | <0.001 | <0.001 | ||
| High | 1.00 | 1.00 | ||
| Moderate | 1.67 (1.47–1.88) | 1.12 (0.99–1.27) | ||
| Poor/undifferentiated | 3.51 (3.06–4.04) | 1.65 (1.42–1.92) | ||
| pT category | <0.001 | <0.001 | ||
| T1 | 1.00 | 1.00 | ||
| T2 | 1.90 (1.50–2.40) | 1.52 (1.19–1.95) | ||
| T3 | 3.50 (2.85–4.31) | 2.19 (1.64–2.92) | ||
| T4 | 7.11 (5.77–8.75) | 3.25 (2.43–4.35) | ||
| pN category | <0.001 | <0.001 | ||
| N0 | 1.00 | 1.00 | ||
| N1 | 2.06 (1.90–2.23) | 1.19 (1.04–1.36) | ||
| N2 | 4.14 (3.82–4.50) | 1.89 (1.66–2.16) | ||
| pM category | <0.001 | <0.001 | ||
| M0 | 1.00 | 1.00 | ||
| M1 | 6.57 (6.11–7.06) | 4.43 (3.45–5.70) | ||
| Clinical stage | <0.001 | <0.001 | ||
| I | 1.00 | 1.00 | ||
| II | 1.87 (1.63–2.15) | 1.00 (0.78–1.27) | ||
| III | 3.55 (3.10–4.07) | 1.45 (1.12–1.87) | ||
| IV | 14.47 (12.61–16.60) | 4.43 (3.45–5.70) | ||
| Pathologic subtype | <0.001 | 0.611 | ||
| Adenocarcinoma | 1.00 | 1.00 | ||
| MA and SRCC | 1.64 (1.48–1.82) | 1.06 (0.94–1.18) | ||
| Othersa | 0.66 (0.53–0.81) | 1.04 (0.84–1.30) | ||
| Operation | <0.001 | <0.001 | ||
| Radical | 1.00 | 1.00 | ||
| Palliative | 7.65 (6.99–8.37) | 2.38 (2.11–2.68) | ||
| Surgical margin | <0.001 | <0.001 | ||
| Negative | 1.00 | 1.00 | ||
| Positive | 6.45 (5.78–7.19) | 1.29 (1.13–1.48) | ||
| Chemotherapy | 0.078 | |||
| No | 1.00 | |||
| Yes | 1.06 (0.99–1.14) | |||
a
Other pathologic subtypes include gastrointestinal stromal tumors, adenosquamous carcinoma, undifferentiated carcinoma, neuroendocrine carcinoma, malignant melanoma, lymph hematopoietic neoplasms, and gastrointestinal mesenchymal tumors.
MA, mucinous adenocarcinoma; SRCC, signet-ring cell carcinoma.