Figure 6.

Relationship between plasma and CSF GFAP with longitudinal amyloid-β accumulation and cognitive decline. Predicted trajectories for longitudinal amyloid-β (Aβ) accumulation determined by PET and MMSE scores (z-scores) in relation to plasma and CSF GFAP in the whole sample, after adjusting for covariates. The models were fit using continuous GFAP values but for illustration purposes the plots show the trajectories for individuals with high and low plasma GFAP for longitudinal amyloid-β-PET (A) and longitudinal MMSE (B) as well as for individuals with high and low CSF GFAP for longitudinal MMSE (C). All results were adjusted for multiple comparisons using FDR (q < 0.05).