. 2021 Jul 8;144(11):3492–3504. doi: 10.1093/brain/awab255

Table 2.

Regional metabolic parameters

	Patients				Healthy volunteers
	Core	Penumbra	Peri-penumbra	Normal appearing	P-value^a		P-value^b
K₁, ml/ml/min	0.039 (0.021)^c,d	0.049 (0.018)^c	0.084 (0.022)^e	0.091 (0.025)	<0.001	0.091 (0.007)	0.720
k₂,/min	0.154 (0.069)	0.131 (0.048)^c	0.156 (0.052)	0.173 (0.055)	<0.001	0.128 (0.029)	<0.001
k₃,/min	0.044 (0.021)^c,d	0.039 (0.010)^c	0.030 (0.012)	0.029 (0.010)	<0.001	0.057 (0.009)	<0.001
K_i, ml/ml/min	0.009 (0.006)^c,d	0.012 (0.004)	0.014 (0.004)	0.013 (0.005)	<0.001	0.034 (0.008)	<0.001
CMRG, µmol/100 ml/min	11.9 (5.4)^c,d	14.9 (4.3)^c	19.5 (4.1)^e	19.9 (4.9)	<0.001	26.3 (1.9)	<0.001
LC	0.48 (0.07)^c,d	0.47 (0.05)^c	0.43 (0.05)^e	0.41 (0.04)	<0.001	0.56 (0.04)	<0.001
CBF, ml/100 ml/min	12.2 (10.7)^c,d	18.1 (6.4)^c	27.4 (8.1)^e	28.6 (4.9)	<0.001	42.9 (11.5)	<0.001
CBV, ml/100 ml	2.7 (0.9)^c,d	2.8 (0.8)^c	3.5 (0.9)^e	4.3 (0.9)	<0.001	3.5 (0.5)	<0.001
CMRO₂, µmol/100 ml/min	29.6 (23.8)^c,d	45.6 (20.6)^c	71.9 (27.3)^e	82.1 (30.5)	<0.001	139.0 (39)	<0.001
OEF, %	30.0 (20.1)^c,d	38.5 (14.4)	42.3 (12.2)	42.1 (10.4)	<0.001	43.9 (4.5)	0.685
Metabolic ratio	2.6 (1.3)^c,d	2.9 (0.8)^c	4.0 (1.2)^e	4.0 (1.2)	<0.001

¹⁸F-FDG kinetic parameters, CMRG, lumped constant (LC), CBF, CBV, CMRO₂, OEF and CMRO₂/CMRG metabolic ratio for the different regions of interest in patients and healthy volunteers. Values are median (IQR).

Kruskal-Wallis test for comparison between core, penumbra, peri-penumbra and normal-appearing regions of interest within patients, with subsequent post hoc Dunn’s tests surviving correction for multiple comparisons (P < 0.005) between each lesion region of interest and normal-appearing brain^c, between core and peri-penumbra^d, and between peri-penumbra and penumbra^e.

Mann-Whitney U-test for comparison between the normal-appearing region of interest in patients versus healthy volunteers.